⛔ This position is no longer available.
University: University of Cambridge
Country: United Kingdom
Deadline: Not specified
Fields: Immunology, Molecular Biology, Biochemistry, Cell Biology, Protein Engineering
Topic: UK – Research Associate in Immunology at University of Cambridge
Fields: Immunology, Molecular Biology, Biochemistry, Cell Biology, Protein Engineering
Position: postdoc
Country: europe
Deadline: Not specified
University: University of Cambridge
Real Country: United Kingdom
Main Category: life & medical sciences
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Are you passionate about unraveling the molecular mechanisms behind immunity and disease, and eager to contribute to cutting-edge research that could transform our understanding of inflammatory and autoimmune disorders?
The University of Cambridge is offering an exceptional opportunity for a talented Research Associate to join a multidisciplinary team at the Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID). This fixed-term postdoctoral position focuses on the study of FAMIN, a conserved enzyme at the heart of energy metabolism, with far-reaching implications for inflammatory diseases such as Still’s disease and Crohn’s disease.
About the University or Research Institute
The University of Cambridge stands as one of the world’s most prestigious academic institutions, renowned for its rigorous research, innovation, and commitment to excellence. Situated in the historic city of Cambridge, England, the university offers a vibrant intellectual environment, attracting top scholars and students globally.
CITIID, a state-of-the-art research facility within the university, is at the forefront of therapeutic immunology and infectious disease research. The institute brings together experts from diverse fields to tackle some of the most pressing medical challenges of our time, fostering collaboration and groundbreaking discoveries. For more information about CITIID, visit their official site: https://www.citiid.cam.ac.uk
Research Topic and Significance
This position centers on investigating FAMIN, an evolutionarily conserved core enzyme pivotal to energy metabolism. The research has revealed that loss-of-function mutations in FAMIN can cause monogenic Still’s disease—a childhood fever syndrome with arthritis—as well as Crohn’s disease, a chronic inflammatory bowel disorder. Notably, certain variants of FAMIN also predispose individuals to leprosy, highlighting its essential role in immune regulation.
Understanding the molecular underpinnings of FAMIN’s function is crucial for developing new therapeutic approaches to treat or prevent these debilitating conditions. The work builds on high-impact publications (Cader et al., Cell 2020; Saveljeva et al., Cell Metab 2022), underscoring the relevance and potential impact of this research.
Project Details
The successful candidate will join Professor Arthur Kaser’s multidisciplinary group at CITIID. The lab is recognized for its innovative approaches to cell and molecular biology, biochemistry, and immunology. The research environment encourages creativity, collaboration, and the pursuit of scientific excellence.
The position is funded for one year in the first instance, with the possibility of extension depending on funding and project progress. The role involves advanced techniques in protein engineering, purification, enzymology, metabolomics, and LC-MS, providing a rich training ground for postdoctoral researchers aiming to deepen their expertise and broaden their research horizons.
For more information about Professor Kaser’s lab, visit: http://www.med.cam.ac.uk/kaser/
Candidate Profile
Ideal candidates will have a strong background in cell and molecular biology, biochemistry, or related fields. Experience in protein engineering, purification, enzymology, metabolomics, and LC-MS is highly desirable. The post is suited for researchers who are passionate about discovery, thrive in multidisciplinary teams, and are motivated to tackle complex scientific questions.
Applicants must have (or be close to obtaining) a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant, with promotion to Research Associate upon confirmation of the award.
The university values diversity and inclusivity, welcoming applications from candidates of all backgrounds.
Application Process
To apply, candidates must submit an online application through the University of Cambridge recruitment portal. Applicants should upload a covering letter and CV, clearly outlining how they meet the criteria for the post and their motivation for applying. Additional documents not requested will not be considered.
Applicants must include details of referees (with email address and phone number), one of whom must be the most recent line manager. Please quote reference RC49230 in your application and all correspondence.
To access the full job advertisement and begin your application, visit:
https://www.jobs.cam.ac.uk/job/55001/
Conclusion
For researchers eager to make a significant impact in immunology and metabolic disease, this position at the University of Cambridge offers an unparalleled opportunity. The role provides access to world-class facilities, mentorship from leading scientists, and the chance to contribute to research with real-world implications. Interested candidates are encouraged to apply promptly and to explore similar opportunities for advancing their academic careers.
Questions & Answers
Question: What is the main focus of this research associate position?
The position focuses on studying the FAMIN enzyme and its role in energy metabolism, inflammation, and autoimmunity, with implications for diseases like Still’s disease and Crohn’s disease.
Question: What qualifications are required for applicants?
Applicants must have, or be close to obtaining, a PhD in cell and molecular biology, biochemistry, or a related field. Experience in protein engineering, purification, enzymology, metabolomics, and LC-MS is desirable.
Question: Is this a permanent position?
No, the position is fixed-term and funded for one year in the first instance.
Question: Where will the research be conducted?
The research will be conducted at the Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge.
Question: How should I apply for this position?
Applications must be submitted online via the University of Cambridge recruitment system. All required documents, including a covering letter and CV, must be uploaded as specified in the advertisement.
Question: Is there a specific application deadline?
No specific deadline is mentioned in the advertisement. Interested candidates are encouraged to apply as soon as possible.
Question: Will I be eligible to work in the UK?
The University of Cambridge will ensure that all employees are eligible to live and work in the UK.
Question: What makes the University of Cambridge an attractive place for postdoctoral research?
Cambridge offers a world-class research environment, access to leading experts, state-of-the-art facilities, and a collaborative, diverse academic community.
Want to calculate your PhD admission chances? Try it here:
https://phdfinder.com/2026/03/12/phd-admission-chance-calculator/
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