⛔ This position is no longer available.
University: Jean Monnet University
Country: France
Deadline: 2026-05-04
Fields: Plant Biochemistry, Molecular Biology, Structural Biology, Biotechnology, Analytical Chemistry
Are you passionate about unraveling the mysteries of plant biochemistry and eager to contribute to groundbreaking research with real-world medical applications? If you are seeking an intellectually stimulating environment to advance your expertise in molecular biology and biochemistry, this fully funded PhD position in France could be the perfect next step in your academic journey.
About the University or Research Institute
Jean Monnet University, located in the vibrant city of Saint-Étienne, France, is a distinguished institution recognized for its commitment to academic excellence and innovative research. The university is home to the Laboratoire de Biotechnologies Végétales (LBVpam), a leading laboratory specializing in plant fragrance and terpenoid biochemistry. LBVpam is renowned for its high-impact contributions to plant science, offering a creative and stimulating international scientific environment equipped with state-of-the-art technologies. The university fosters an atmosphere of collegial respect, academic freedom, and responsibility, making it an ideal setting for ambitious researchers aiming to push the boundaries of knowledge.
France itself is celebrated for its world-class research infrastructure, rich cultural heritage, and high quality of life. International students in France benefit from a dynamic academic community, robust funding opportunities, and access to a wide network of scientific collaborations across Europe.
Research Topic and Significance
The focus of this PhD project is the elucidation of the biosynthetic pathway of thapsigargin in Thapsia garganica—an area of plant biochemistry with profound ecological, industrial, and medical relevance. Terpenes, the largest class of natural products, are central to plant ecology and have significant industrial applications, including in the fragrance and pharmaceutical sectors.
Thapsigargin, a sesquiterpenoid produced by Thapsia garganica, holds major medical interest due to its established use in oncology and virology. However, the full biosynthetic pathway of thapsigargin remains incompletely understood. This research aims to fill critical gaps in our knowledge, paving the way for the development of sustainable, environmentally friendly, and economically viable production methods for this valuable molecule. The project’s outcomes could have substantial impacts on the production of plant-derived pharmaceuticals, enhancing their accessibility and sustainability.
Project Details
The PhD project is a collaboration between Professor Henrik Toft Simonsen at the Laboratoire de Biotechnologies Végétales (LBVpam), Saint-Étienne, and Frédéric Bourgaud at Laboratoire Réactions et Génie des Procédés, Nancy. The majority of the research will be conducted in Saint-Étienne, with shorter research stays in Nancy for specialized biotechnological studies.
The research will involve:
– RNA extraction from various root cells of Thapsia garganica.
– Co-expression studies and in-planta biochemical characterization (using Nicotiana benthamiana) of cytochrome P450s and other enzymes involved in thapsigargin biosynthesis.
– Heterologous expression of newly discovered enzymes in yeast in Nancy laboratories.
– Application of advanced cell mapping and metabolic engineering tools to investigate the underlying molecular mechanisms.
The project is funded by the CNRS MITI program and adheres to CNRS regulations. The successful candidate will be enrolled in the doctoral school 488 Sciences Ingénierie Santé SIS, ensuring a structured and supportive PhD training experience.
Candidate Profile
This opportunity is ideally suited for candidates who aspire to build a career in plant biochemistry and molecular biology, with a strong interest in terpenoid biochemistry. The following qualifications and attributes are expected:
– A Master of Science (or engineering) degree in Molecular Biology, Biochemistry, or closely related fields.
– Preferably prior experience in plant molecular biology.
– Some knowledge of bioinformatics and cell physiology.
– Familiarity with enzyme characterization, cloning techniques, and analytical chemistry is advantageous.
– Proficiency in scientific English (both written and spoken), as it is the working language in the laboratories.
– Motivation to engage in international and interdisciplinary research, including willingness to spend 2-3 months in Nancy, France, as part of the project.
Candidates should demonstrate curiosity, perseverance, and a collaborative spirit, as well as the ability to contribute to a diverse and international research group.
Application Process
Applications are accepted exclusively via the official CNRS portal (https://emploi.cnrs.fr/) between April 13, 2026, and May 4, 2026. For more information, you can contact Henrik Toft Simonsen at henrik.toft.simonsen@univ-st- etienne.fr.
Conclusion
If you are driven by scientific discovery and eager to make a meaningful impact in plant biochemistry and biotechnology, this PhD position at Jean Monnet University offers a unique platform to advance your career. Take advantage of France’s world-class research environment and join a team at the forefront of innovation. Be sure to apply before the deadline, and explore similar opportunities to further your academic ambitions.
Questions & Answers
Question: What are the main research techniques I will learn during this PhD?
You will gain hands-on experience in RNA extraction, molecular cloning, enzyme characterization, in-planta biochemical assays, metabolic engineering, and heterologous protein expression in yeast, along with bioinformatics and analytical chemistry methods.
Question: Is knowledge of French required for this PhD position?
No, the working language in the laboratory is English, so proficiency in English is essential. However, living in France offers a great opportunity to learn French for daily life and cultural integration.
Question: What are the career prospects after completing this PhD?
Graduates will be well-prepared for careers in academia, biotechnology, pharmaceutical industries, and research institutes, especially in roles focusing on plant biochemistry, metabolic engineering, and molecular biology.
Question: Are there opportunities for international collaboration?
Yes, the project involves collaboration between laboratories in Saint-Étienne and Nancy, and you will be part of a diverse international scientific community, with access to networks across France and Europe.
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