⛔ This position is no longer available.
University: University of Zurich
Country: Switzerland
Deadline: Rolling
Fields: Microbial Synthetic Biology, Molecular Biology, Genetic Engineering, Biomedical Sciences, Antimicrobial Research
Are you passionate about harnessing the power of microbes to develop next-generation antimicrobial therapies, and eager to advance your career in a leading European research environment?
The Department of Quantitative Biomedicine at the University of Zurich is offering an exciting, fully funded postdoctoral position in Microbial Synthetic Biology, with a focus on engineering nonribosomal peptide synthetases (NRPSs) in Pseudomonas species. This opportunity is ideal for researchers keen to contribute to innovative biomedical solutions and collaborate within a dynamic interdisciplinary team.
About the University or Research Institute
The University of Zurich (UZH) is one of Switzerland’s premier institutions and a leader in interdisciplinary research and teaching. Located in the vibrant city of Zurich, UZH is renowned for its commitment to academic excellence, innovation, and societal impact. The Department of Quantitative Biomedicine stands at the intersection of basic science and translational medicine, fostering collaboration among biologists, chemists, clinicians, and data scientists. With state-of-the-art facilities and a strong culture of international collaboration, UZH provides a stimulating environment for researchers to thrive.
Switzerland itself is known for its high quality of life, excellent public services, and a strong tradition of scientific research and innovation. Living in Zurich, you will benefit from a multicultural atmosphere, outstanding public transportation, and access to breathtaking natural landscapes.
Research Topic and Significance
This postdoctoral project centers on the rational design and engineering of nonribosomal peptide synthetases (NRPSs) in Pseudomonas species to generate novel iron-binding peptides with potent antimicrobial activity. In the context of rising antimicrobial resistance and the urgent need for new therapeutic agents, this research is highly relevant. By leveraging synthetic biology and genetic engineering, the project aims to develop innovative compounds that could pave the way for future clinical applications, potentially transforming the landscape of antimicrobial treatment.
The Kümmerli lab, embedded within the Department of Quantitative Biomedicine, is dedicated to understanding microbial interactions and developing new antimicrobial strategies. The lab’s expertise in bacterial pathogenesis and translational research ensures a robust foundation for impactful discoveries.
Project Details
The successful candidate will join a multidisciplinary team and work closely with a chemistry postdoc to engineer NRPS biosynthetic pathways in Pseudomonas species. The main responsibilities include:
– Rational design and genetic engineering of peptide derivatives in Pseudomonas.
– Purification and characterization of novel peptide variants.
– Quantification of antimicrobial activity against clinically relevant bacterial strains.
– Participation in in vivo infection experiments using zebrafish larvae to assess toxicity and efficacy.
– Close collaboration with a synthetic chemist for downstream chemical modifications.
– Data analysis, documentation, and contribution to scientific publications.
The position is fully funded for 18 months by Innosuisse and offers a collaborative, supportive research environment with flexible working models, childcare support, and a strong emphasis on work-life balance.
Candidate Profile
This position is ideally suited for candidates who possess:
– A PhD in synthetic biology, molecular biology, or a closely related field.
– Demonstrated hands-on experience in bacterial genetic engineering.
– Solid understanding of secondary metabolite biosynthesis or NRPS systems.
– Ability to work independently and manage a research project effectively.
– Strong collaboration skills and experience working in multidisciplinary teams.
– A keen interest in translational research and antimicrobial development.
– Proficiency in spoken and written English.
Applicants should be motivated, innovative, and committed to advancing the field of microbial synthetic biology for real-world biomedical applications.
Application Process
Applications are accepted on a rolling basis until the position is filled. Interested candidates should submit a single PDF application including a motivation letter, CV, publication list, and contact information for at least two references via the following link:
Conclusion
This is a unique opportunity for postdoctoral researchers who aspire to make a tangible impact in the fight against antimicrobial resistance while working at a world-class institution in the heart of Europe. If you are ready to take on challenging research and contribute to the development of innovative biomedical solutions, we encourage you to apply. For more opportunities like this, be sure to follow updates and explore related positions.
Questions & Answers
Question: What makes Switzerland, and particularly Zurich, an attractive destination for postdoctoral researchers?
Switzerland offers a high standard of living, excellent research infrastructure, and a multicultural environment. Zurich is known for its vibrant academic community, safety, and proximity to nature, making it an ideal place for both professional and personal growth.
Question: How does this project contribute to the global challenge of antimicrobial resistance?
By engineering novel antimicrobial peptides through synthetic biology, the project aims to develop new therapeutic agents that could help address the urgent need for effective treatments against resistant bacterial pathogens.
Question: What kind of collaboration can I expect in this position?
You will work closely with a synthetic chemist and be part of a multidisciplinary team, fostering collaboration between biologists, chemists, and clinicians to drive translational research.
Question: Are there flexible working arrangements and support for work-life balance?
Yes, the University of Zurich offers flexible working models, including part-time options, mobile working, job-sharing, and on-campus childcare, supporting a healthy work-life balance.
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